Strategic approaches to drug design. II. Modelling studies on phosphodiesterase substrates and inhibitors |
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Authors: | A Davis B H Warrington J G Vinter |
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Institution: | (1) Smith Kline & French Research, The Frythe, AL6 9AR Welwyn, Herts, U.K. |
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Abstract: | Summary Modelling studies have been carried out on the phosphodiesterase (PDE) substrates, adenosine- and guanosine-3 5 -cyclic monophosphates, and on a number of non-specific and type III-specific phosphodiesterase inhibitors. These studies have assisted the understanding of PDE substrate differentiation and the design of potent, selective PDE type III inhibitors. |
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Keywords: | Phosphodiesterase inhibitors Cyclic nucleotides Molecular modelling |
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