HPLC-ICP-MS and HPLC-ES-MS/MS characterization of synthetic seleno-arsenic compounds |
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Authors: | Katerina Kanaki Spiros A Pergantis |
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Institution: | (1) Environmental Chemical Processes Laboratory, Department of Chemistry, University of Crete, Voutes, 71003 Heraklion, Crete, Greece |
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Abstract: | Various toxicological and metabolic interactions have been reported to exist between arsenic and selenium. In the present
study, synthetic seleno-arsenic compounds, potentially suitable for probing metabolic interactions between these two elements,
were prepared and tentatively characterized by using high-performance liquid chromatography (HPLC)–electrospray tandem mass
spectrometry and HPLC–inductively coupled plasma mass spectrometry. In analogy to the recently identified thio-arsenic species,
which can be prepared from their corresponding oxo-arsenic species via reaction with H2S, the seleno-arsenic compounds were also derived from oxo-arsenic compounds via reaction with H2Se.
Figure H2Se bubbled into solutions containing oxo‐arsenosugars converts them into their seleno‐arsenosugar analogues. |
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Keywords: | Arsenic Selenium Speciation Inductively coupled plasma mass spectrometry Electrospray tandem mass spectrometry |
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