| 肝靶向甘草次酸修饰的壳聚糖纳米粒子的合成和表征 |
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| 引用本文： | 查瑞涛,贺晓婷,杜田,袁直. 肝靶向甘草次酸修饰的壳聚糖纳米粒子的合成和表征[J]. 高等学校化学学报, 2007, 28(6): 1098-1100 |
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| 作者姓名： | 查瑞涛 贺晓婷 杜田 袁直 |
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| 作者单位： | 南开大学高分子化学研究所,功能高分子材料教育部重点实验室,天津,300071;天津科技大学材料科学与化学工程学院,天津,300457;南开大学高分子化学研究所,功能高分子材料教育部重点实验室,天津,300071 |
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| 基金项目： | 教育部天津大学-南开大学科技合作基金 , 天津市自然科学基金 |
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| 摘 要： | 合成了修饰甘草次酸的壳聚糖(GA-CTS), 采用离子交联法制备了GA-CTS纳米粒子. 该材料可能具有肝细胞主动靶向作用, 为进一步的肝靶向药物控释的研究奠定了基础.
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| 关 键 词： | 甘草次酸 壳聚糖 肝靶向 |
| 文章编号： | 0251-0790（2007）06-1098-03 |
| 收稿时间： | 2006-12-04 |
| 修稿时间： | 2006-12-04 |
Synthesis and Characterization of Chitosan Nanoparticles Modified by Glycyrrhetinic Acid as a Liver Targeting Drug Carrier |
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| ZHA Rui-Tao,HE Xiao-Ting,DU Tian,YUAN Zhi. Synthesis and Characterization of Chitosan Nanoparticles Modified by Glycyrrhetinic Acid as a Liver Targeting Drug Carrier[J]. Chemical Research In Chinese Universities, 2007, 28(6): 1098-1100 |
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| Authors: | ZHA Rui-Tao HE Xiao-Ting DU Tian YUAN Zhi |
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| Affiliation: | Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China;;College of Material Science and Chemical Engineering, Tianjin University of Science &; Technology, Tianjin 300457, China
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| Abstract: | Chitosan derivative with glycyrrhetinic acid(GA),which was accumulated specifically in liver,was synthesized.By ion-crosslinking of TPP in GA-CTS solution,GA-CTS-TPP complex nanoparticles were obtained.The physicochemical properties of these nanoparticles were investigated by using TEM and DLS.The experiment in vitro BSA entrapped was studied.GA-CTS-TPP nanoparticles are well dispersed and stable in aqueous solution in 14 months. |
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| Keywords: | Glycyrrhetinic acid Chitosan Liver targeting |
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