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1-Substituted 2-Azaspiro[3.3]heptanes: Overlooked Motifs for Drug Discovery |
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| Authors: | Alexander A. Kirichok Dr. Iryna Shton Dr. Maria Kliachyna Dr. Iryna Pishel Dr. Pavel K. Mykhailiuk |
| Affiliation: | 1. Enamine Ltd./Bienta, Chervonotkatska 78, 02094 Kyiv, Ukraine;2. Taras Shevchenko National University of Kyiv, Chemistry Department, Volodymyrska 64, 01601 Kyiv, Ukraine |
| Abstract: | The 2-substituted piperidine core is found in drugs (18 FDA-approved drugs), however, their spirocyclic analogues remain unknown. Described here is the synthesis of spirocyclic analogues for 2-substituted piperidines and a demonstration of their validation in drug discovery. |
| Keywords: | drug discovery heterocycles small rings spirocycles synthetic methods |