Enantioselective Propargylation of Polyols and Desymmetrization of meso 1,2-Diols by Copper/Borinic Acid Dual Catalysis |
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| Authors: | Ren-Zhe Li Hua Tang Dr. Ke R. Yang Li-Qiang Wan Xia Zhang Jie Liu Zhengyan Fu Prof. Dawen Niu |
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| Affiliation: | 1. Department of Emergency, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, No. 17 Renmin Nan Road, Chengdu, 610041 China;2. Department of Chemistry, Yale University, New Haven, CT, 06520-8107 USA |
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| Abstract: | A copper/borinic acid dual catalytic reaction enabled the enantioselective propargylation of aliphatic polyols. Readily available reagents and catalysts were used in this transformation, which displayed good to excellent chemo- and stereoselectivity for a broad array of substrates. The method was also applicable to the desymmetrization of meso 1,2-diols to furnish products with three stereogenic centers and a terminal alkyne group in one operation. |
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| Keywords: | alcohols copper desymmetrization dual catalysis propargylation |
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