Iron-Catalyzed Intermolecular 1,2-Difunctionalization of Styrenes and Conjugated Alkenes with Silanes and Nucleophiles |
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| Authors: | Yuan Yang Dr Ren-Jie Song Xuan-Hui Ouyang Cheng-Yong Wang Prof Dr Jin-Heng Li Prof Dr Shenglian Luo |
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| Institution: | 1. Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle, Nanchang Hangkong University, Nanchang, 330063 China
State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, 410082 China;2. Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle, Nanchang Hangkong University, Nanchang, 330063 China |
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| Abstract: | The first iron-catalyzed 1,2-difunctionalization of styrenes and conjugated alkenes with silanes and either N or C, using an oxidative radical strategy, is described. Employing FeCl2 and di-tert-butyl peroxide allows divergent alkene 1,2-difunctionalizations, including 1,2-aminosilylation, 1,2-arylsilylation, and 1,2-alkylsilylation, which rely on a wide range of nucleophiles, namely, amines, amides, indoles, pyrroles, and 1,3-dicarbonyls, thus providing a powerful platform for producing diverse silicon-containing alkanes. |
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| Keywords: | alkenes iron radicals reaction mechanisms silanes |
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