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Amide-Directed C?H Sodiation by a Sodium Hydride/Iodide Composite |
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| Authors: | Dr Yinhua Huang Guo Hao Chan Prof Shunsuke Chiba |
| Institution: | 1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637371 Singapore
These authors contributed equally.;2. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637371 Singapore |
| Abstract: | A new protocol for amide-directed ortho and lateral C?H sodiation is enabled by sodium hydride (NaH) in the presence of either sodium iodide (NaI) or lithium iodide (LiI). The transient organosodium intermediates could be transformed into functionalized aromatic compounds. |
| Keywords: | Amide Arene C-H-Aktivierung Metallierungen Natriumhydrid |