Iridium-Catalyzed Formyl-Selective Deuteration of Aldehydes |
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| Authors: | Prof Dr William J Kerr Dr Marc Reid Dr Tell Tuttle |
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| Institution: | Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow, Scotland, G1 1XL UK |
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| Abstract: | We report the first direct catalytic method for formyl-selective deuterium labeling of aromatic aldehydes under mild conditions, using an iridium-based catalyst designed to favor formyl over aromatic C−H activation. A good range of aromatic aldehydes is selectively labeled, and a one-pot labeling/olefination method is also described. Computational studies support kinetic product control over competing aromatic labeling and decarbonylation pathways. |
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| Keywords: | aldehydes C−H activation deuteration DFT iridium |
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