Dicobalt octacarbonyl promoted rearrangement of 4-isoxazolines to acylaziridines: dramatic rate acceleration with very high substrate tolerance |
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| Authors: | Ishikawa Teruhiko Kudoh Takayuki Yoshida Juri Yasuhara Ayako Manabe Shinobu Saito Seiki |
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| Institution: | Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University, Tsushima, Okayama, Japan 700-8530. sesaito@biotech.okayama-u.ac.jp |
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| Abstract: | reaction: see text] Dicobalt octacarbonyl Co(2)(CO)(8)] in acetonitrile at 75 degrees C triggers the cleavage of the N-O bond of 4-isoxazolines (1) to bring about the valence rearrangement to 2-acylaziridines (2). The isoxazolines were stable at 75 degrees C in the absence of the cobalt complex. |
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