Synthesis and antifungal activity of (-)-(Z)-dysidazirine |
| |
Authors: | Skepper Colin K Dalisay Doralyn S Molinski Tadeusz F |
| |
Institution: | Department of Chemistry and Biochemistry and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, USA. |
| |
Abstract: | A short, flexible synthesis of the marine natural product (2 R)-(Z)-dysidazirine (-)-1 has been completed. (-)-1 shows significant antifungal activity across a panel of seven human pathogens, whereas the structural analogue (-)-2, featuring a terminal tert-butyl group, is essentially inactive. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|