Electrochemical properties and square-wave voltammetric determination of pravastatin |
| |
Authors: | Biljana Nigović |
| |
Affiliation: | (1) Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia |
| |
Abstract: | The electrochemical reduction and adsorptive voltammetric behaviour of pravastatin have been studied by means of cyclic and square-wave voltammetry at a hanging mercury-drop electrode in electrolytes of different pH. Within the entire pH range (2.0–9.0) in Britton–Robinson buffer, pravastatin gave rise to a single voltammetric peak in the potential interval from −1.22 to −1.44 V, depending on pravastatin concentration. It was found that the reduction of pravastatin proceeds via a relatively stable intermediate, which is transformed to the final electroinactive product by a coupled chemical reaction or can be re-oxidized back to pravastatin. The rate of chemical transformation is controlled by the proton concentration. The electrode mechanism has the properties of a surface redox reaction. A sensitive analytical method for trace analysis of pravastatin based on the adsorptive stripping technique has been developed. The calibration plot was linear in the range 8×10−8–5×10−7 mol L−1. Application of the square-wave voltammetric method to determination of pravastatin in a pharmaceutical dosage form, without sample pretreatment, resulted in acceptable deviation from the stated concentration. |
| |
Keywords: | Pravastatin Square-wave voltammetry Adsorptive stripping voltammetry Hanging mercury-drop electrode Pharmaceutical dosage forms |
本文献已被 PubMed SpringerLink 等数据库收录! |
|