The osmotic pressure of concentrated protein and lipoprotein solutions and its significance to ultrafiltration |
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| Authors: | Vincent L Vilker Clark K Colton Kenneth A Smith Donald L Green |
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| Institution: | Department of Chemical Engineering, University of California, Los Angeles, Los Angeles, CA 90024 U.S.A.;Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 U.S.A. |
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| Abstract: | Side-by-side measurements were made of osmotic pressure and ultrafiltration flux from a stirred cell for separate saline solutions of the proteins, bovine serum albumin, bovine fibrinogen, human low density lipoprotein and for polyethylene oxide .in distilled water. Albumin osmotic pressures were large enough to conclude that concentration polarization limits ultrafiltrate flux mostly by decreasing the driving forceΔP -Δπ. For the other large macrosolutes, concentrated-solution osmotic pressures were so small that polarization probably limits flux at the usual levels of applied pressure by adding a hydrodynamic resistance (gel layer) in series with the membrane resistance. |
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| Keywords: | To whom correspondence should be addressed |
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