Absolute stereochemistry of amphidinolide E |
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| Authors: | Kubota Takaaki Tsuda Masashi Kobayashi Jun'ichi |
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| Institution: | Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. |
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| Abstract: | The absolute configurations at eight chiral centers in amphidinolide E (1), a cytotoxic 19-membered macrolide isolated from a marine dinoflagellate Amphidinium sp., were determined to be 2R, 7R, 8R, 13S, 16S, 17R, 18R, and 19R on the basis of detailed analysis of NMR data and by chemical means. |
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