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Polynuclear heterocyclic compounds containing an indole fragment
Authors:V I Shvedov  L B Altukhova  V V Alekseev  A N Grinev
Institution:(1) S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, Moscow
Abstract:Derivatives of 6,7,9,10,11,12-hexahydro-5H-indolo3,2,1-d,e]phenazine and 1,2,3,4-tetrahydroindolo1,2-a]quinoxaline were obtained by condensation of the sodium derivatives of 1-keto-1,2,3,4-tetrahydrocarbazoles and 2-aroylindoles, respectively, withagr-bromocyclohexanone dimethylketal. These compounds are converted to derivatives of indolo1,2-a]-quinoxaline, 5,6-dihydroindolo1,2-a]quinoxaline, and 8a,9,10,11,12,12a-hexahydro- and 5,6,7,7a,8a,9,10,11,12,12a-decahydro-8H-indolo3,2,1-d,e]phenazine by dehydrogenation over a Raney nickel catalyst and reduction with sodium in alcohol.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1348–1352, October, 1970.
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