Enantioselective organocatalytic synthesis of fluorinated molecules |
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Authors: | Valero Guillem Companyó Xavier Rios Ramon |
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Institution: | Departament de Química Orgànica, Universitat de Barcelona, 08028 Barcelona, Spain. |
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Abstract: | The enantioselective synthesis of fluorinated molecules has drawn much attention within the chemical community due to its unique stereoelectronic properties. The main aim of this review is to cover the most important organocatalytic enantioselective methodologies to obtain them. The review is divided into three parts: first, the direct introduction of a fluorine atom studied in the early 2000s. Second, the later use of Michael reactions to introduce fluorine-containing synthons. Finally, the simultaneously-developed trifluoromethylation reactions, giving the catalysts, mechanisms and reagents that have been used. |
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Keywords: | enamines fluorine Michael reaction organocatalysis trifluoromethylation |
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