Synthesis of fluorescent probes based on the pyochelin siderophore scaffold |
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Authors: | Noël Sabrina Guillon Laurent Schalk Isabelle J Mislin Gaëtan L A |
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Institution: | UMR 7242 Biotechnologie et Signalisation Cellulaire, Universite? de Strasbourg-CNRS, ESBS, Illkirch, France. |
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Abstract: | Pyochelin is a siderophore common to several pathogenic bacterial strains. Two conjugates, 1 and 2, between the NBD (4-nitro-benzo1,2,5]oxadiazole) fluorophore and an N3'-functionalized pyochelin were synthesized. These fluorescent probes unexpectedly increased their fluorescence in an aqueous medium in the presence of iron(III) and were transported into bacterial cells. |
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