| Synthesis of Indomethacin Conjugates with D-Glucosamine |
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| 作者姓名： | YiChunZHANG YingXiaLI HuaShiGUAN |
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| 作者单位： | KeyLaboratoryofMarineDrugs,MinistryofEducation,MarineDrugandFoodInstitute,OceanUniversityofChina,Qingdao266003 |
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| 摘 要： | Two series of indomethacin conjugates with D-glucosamine were prepared with the objectives of reducing ulcerogenic potency, increasing the bioavailability of indomethacin and exerting the coordinative effects on osteoarthritis. The structures of the conjugates were identified by ^1H NMR and ^13C NMR. The ester conjugates inhibited edema as potent as indomethacin.
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| 关 键 词： | 消炎镇痛药 合成方法 茚甲新 D-葡糖胺 NSAIDs 药物分析 |
Synthesis of Indomethacin Conjugates with D-Glucosamine |
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| YiChunZHANG YingXiaLI HuaShiGUAN.Synthesis of Indomethacin Conjugates with D-Glucosamine[J].Chinese Chemical Letters,2005,16(2):179-182. |
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| Authors: | Yi Chun ZHANG Ying Xia LI Hua Shi GUAN Key Laboratory of Marine Drugs Ministry of Education Marine Drug and Food Institute Ocean University of China Qingdao |
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| Institution: | Yi Chun ZHANG,Ying Xia LI*,Hua Shi GUAN Key Laboratory of Marine Drugs,Ministry of Education,Marine Drug and Food Institute,Ocean University of China,Qingdao 266003 |
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| Abstract: | Two series of indomethacin conjugates with D-glucosamine were prepared with theobjectives of reducing ulcerogenic potency, increasing the bioavailability of indomethacin andexerting the coordinative effects on osteoarthritis. The structures of the conjugates were identifiedby H NMR and C NMR. The ester conjugates inhibited edema as potent as indomethacin. 1 13 |
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| Keywords: | Indomethacin D-glucosamine NSAIDs glycoconjugates |
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