Preparation of brassylic acid from 5,6,7,8,9,10,11,12,13,14-decahydrocyclododeca[1,2-d]pyrimidine(1H, 3H)-2,4-dione obtained by the condensation of cyclododecanone and urea or biuret

A simple method is proposed for the preparation of brassylic acid by the alkaline hydrolysis of 5,6,7,8,9,10,11,12,13,14-decahydrocyclododeca[1,2-d]pyrimidine(1H, 3H)dione-2,4, which is the product of the condensation of cyclododecanone with urea or biuret. The condensation of the cyclododecanone with thiourea proceeds differently, leading to 5,6,7,8,9,10,11,12,13,14-decahydrocyclododeca[1,2-d]pyrimidine(1H, 3H)spirocyclododecane-2-thione-4.A. N. Nesmeyanov Institute of Organometallic Compounds, Russian Academy of Sciences, 117813 Moscow. Translated from Izvestiya Akademii Nauk, Seriya Khimicheskaya, No. 1, pp. 226–229, January, 1992.