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LINKED-FUNCTION ANALYSIS OF FLUORESCENCE DECAY KINETICS: RESOLUTION OF SIDE-CHAIN ROTAMER POPULATIONS OF A SINGLE AROMATIC AMINO ACID IN SMALL POLYPEPTIDES |
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| Authors: | J. B. Alexander Ross William R. Laws John Clark Sutherland Angeliki Buku Panayotis G. Katsoyannis Irving L. Schwartz Herman R. Wyssbrod |
| Affiliation: | Department of Biochemistry, New York, NY 10029, USA;Center for Polypeptide and Membrane Research, New York, NY 10029, USA;Department of Physiology and Biophysics, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA;Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA |
| Abstract: | A linked-function approach to fluorescence decay data analysis is presented that permits complex systems to be resolved from a single decay curve. The method involves linking fluorescence decay parameters based on a relationship established by independent physical measurements. As an example, by correlating the fluorescence data with |
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