Titanium cis‐1,2‐Diaminocyclohexane (cis‐DACH) Salalen Catalysts for the Asymmetric Epoxidation of Terminal Non‐Conjugated Olefins with Hydrogen Peroxide |
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| Authors: | Dr Qifang Wang Dr Jörg‐M Neudörfl Prof?Dr Albrecht Berkessel |
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| Institution: | 1. University of Cologne, Department of Chemistry, Organic Chemistry, Greinstrasse 4, 50939 Cologne (Germany), Fax: (+49)?221‐470‐5102;2. X‐Ray crystallography |
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| Abstract: | Chiral Ti salalen complexes catalyze the asymmetric epoxidation of terminal non‐conjugated olefins with hydrogen peroxide. Modular ligands based on cis‐1,2‐diamino‐cyclohexane (cis‐DACH) were developed, giving high yields and enantiomeric excesses (ee, up to 96 %) at catalyst loadings as low as 0.1–0.5 mol %, and even under solvent‐free conditions. |
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| Keywords: | asymmetric synthesis epoxidation hydrogen peroxide terminal olefins titanium |
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