|
|||||
|
|
A Free‐Blockage Controlled Release System Based on the Hydrophobic/Hydrophilic Conversion of Mesoporous Silica Nanopores |
|
| Authors: | Dr Wenqian Wang Dr Linfeng Chen Prof Li‐ping Xu Prof Hongwu Du Prof Yongqiang Wen Prof Yanlin Song Prof Xueji Zhang |
| Institution: | 1. Research Centre for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083 (P. R. China);2. Key Laboratory of Green Printing, Key Lab of Organic Solids, Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P. R. China) |
| Abstract: | A pH‐responsive free‐blockage release system was achieved through controlling the hydrophobic/hydrophilic conversion of mesoporous silica nanopores. This system further presented pulsatile release with changing pH values between 4.0 and 7.0 for several cycles. This free‐blockage release system could also release antitumor agents to induce cell death after infecting tumor cells and could have the ability of continuous infection to tumor cells with high drug‐delivery efficiency and few side effects. |
| Keywords: | controlled release drug delivery hydrophobic/hydrophilic effects mesoporous materials silica |