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Dynamic Combinatorial Enrichment of Polyconformational D‐/L‐Peptide Dimers |
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| Authors: | Dr Kirtikumar B Jadhav Dr Roman J Lichtenecker Anke Bullach Dr Bhubaneswar Mandal Prof?Dr Hans‐Dieter Arndt |
| Institution: | 1. Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich‐Schiller‐University, Humboldtstr. 10, 07743 Jena (Germany), Fax: (+49)?3641‐9‐48212;2. Current address: Institute of Organic Chemistry, University of Vienna, W?hringerstr. 38, 1090 Vienna (Austria);3. Current address: INFU, TU Dortmund, Otto‐Hahn‐Str. 6, 44221 Dortmund (Germany);4. Current address: Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, Assam 781039 (India) |
| Abstract: | D ‐/L ‐Peptides such as gramicidin A (gA) adopt unique dimeric β‐helical structures of different topologies. To overcome their conformational promiscuity and enrich individual components, a dynamic combinatorial approach assisted by thiol tags was developed. This method led to identification of the preferential formation of antiparallel dimers under a broad range of conditions, which was independent of peptide side‐chain polarity. Exclusive formation of an antiparallel cyclic dimer was achieved in the presence of cesium ions. |
| Keywords: | disulfides combinatorial chemistry gramicidin A peptides beta‐helix |