High Impact of Uranyl Ions on Carrying–Releasing Oxygen Capability of Hemoglobin‐Based Blood Substitutes |
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| Authors: | Prof Li Duan Lili Du Dr Yi Jia Prof Wenyuan Liu Prof Zhichao Liu Prof Junbai Li |
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| Institution: | 1. Northwest Institute of Nuclear Technology, Xi‘an, Shaanxi 710024 (P. R. China);2. Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Colloid Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190 (P. R. China) |
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| Abstract: | The effect of radioactive UO22+ on the oxygen‐transporting capability of hemoglobin‐based oxygen carriers has been investigated in vitro. The hemoglobin (Hb) microspheres fabricated by the porous template covalent layer‐by‐layer (LbL) assembly were utilized as artificial oxygen carriers and blood substitutes. Magnetic nanoparticles of iron oxide (Fe3O4) were loaded in porous CaCO3 particles for magnetically assisted chemical separation (MACS). Through the adsorption spectrum of magnetic Hb microspheres after adsorbing UO22+, it was found that UO22+ was highly loaded in the magnetic Hb microspheres, and it shows that the presence of UO22+ in vivo destroys the structure and oxygen‐transporting capability of Hb microspheres. In view of the high adsorption capacity of UO22+, the as‐assembled magnetic Hb microspheres can be considered as a novel, highly effective adsorbent for removing metal toxins from radiation‐contaminated bodies, or from nuclear‐power reactor effluent before discharge into the environment. |
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| Keywords: | hemoglobin microspheres LbL assembly magnetic Fe3O4 particles porous CaCO3 uranyl ion |
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