药物配体与生物大分子受体相互作用核磁共振的研究进展

药物与生物体内目标大分子之间的相互作用，是决定药物药理活性和代谢稳定性的主要因素。如何快速高效地识别出能与靶分子相互作用且能抑制其体外活性的药物分子，是制药工业普遍关注的问题。核磁共振已经成为研究小分子配体和生物大分子相互作用的一种非常重要的手段。检测小分子配体信号在作用过程中的变化以识别药物分子，是核磁共振进行药物筛选的主要方法之一。本文介绍了近年来这方面的研究进展。

Progress in Nuclear Magnetic Resonance Study on the Interaction between Drug Ligand and Macromolecular Receptor

The interaction between drug and target macromolecule in vivo is one of the most important factors that determine the therapeutic activity and metabolic stability of the drug. How to rapidly and efficiently discover drug that can interact with target molecular and inhibit its in vitro activity has become an issue of major concern in pharmaceutical industries. Nuclear magnetic resonance (NMR) is now a very important approach to study the interaction between small ligand and biomolecule. Both ligand and receptor experience changes in the interaction process. Drug screening by NMR can be achieved by monitoring signals from ligand . The recent developments in this field are reviewed.