| Synthesis and relaxivity of Gd(Ⅲ), Fe(Ⅲ) and Mn(Ⅱ) complexes with dihydropyridine derivative of diethvlenetriaminepentaacetic acid |
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| 作者姓名： | CHANG Jianhua ZHENG Shuzhan JIAN Yajun BAI Yinjuan & ZHANG Shiping |
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| 作者单位： | CHANG Jianhua，ZHENG Shuzhan，JIAN Yajun，BAI Yinjuan & ZHANG Shiping Department of Chemistry，Northwest University，Xi'an 710069，China |
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| 摘 要： | A novel ligand of DTPA-dihydropyridine derivative was synthesized by reaction of DTPA-dianhydride with 4-aniline-1,4-dihydropyridine. Its complexes of gadolinium, manganese and iron were prepared. Their spin-lattice relaxivities (T1) were investigated. The results show that the NMR T1 relaxivitives (R1) for complexes of Fe(Ⅲ), Mn(Ⅱ) are less than that of Gd(Ⅲ) complex, which has a high relaxivity (R1) on the surrounding water protons, indicating that the Gd(Ⅲ) complex possesses the precondition to be contrast agents for magnetic resonance imaging.
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