Increase of separation resolution through field enhancement in microchips |
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Authors: | Kerby Matthew B Chien Ring-Ling |
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Institution: | Caliper Technologies Corp., 605 Fairchild Drive, Mountain View, CA 94043, USA. |
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Abstract: | An enhanced ability to separate charged species from neutral compounds in a microfluidic chip is demonstrated using a chip design with low-resistance electrode channels operating with a multiport pressure/voltage controller. A factor of 2.7 improvement in resolution was obtained from chips made using identical mask designs but different etch depth protocols. Greater separation power allows one to cover a wider dynamic range for compounds with different electrophoretic mobilities. |
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