Nickel-catalyzed highly regioselective multicomponent coupling of ynamides, aldehydes, and silane: a new access to functionalized enamides |
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| Authors: | Saito Nozomi Katayama Tomoyuki Sato Yoshihiro |
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| Affiliation: | Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. |
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| Abstract: | A new method for preparation of functionalized enamides by a nickel-catalyzed multicomponent coupling of ynamides, aldehydes, and silane has been developed. The coupling reaction proceeded in the presence of a nickel-IMes catalyst to give the corresponding gamma-silyloxyenamide derivative, which has an allylic alcohol moiety in the molecule, in a highly stereoselective manner. |
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