Synthesis and cytotoxicity of methyl-and methoxy-substituted metal 8-quinolinethiolates |
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Authors: | E. Lukevics D. Zaruma J. Ashaks I. Shestakova I. Domracheva A. Gulbe V. Bridane |
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Affiliation: | (1) Latvian Institute of Organic Synthesis, Riga, LV-1006, Latvia;(2) Inorganic Chemistry Institute, Riga Technical University, Salaspils, LV-2169, Latvia |
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Abstract: | It has been found that the nature of the substituent, its position in the quinoline ring, and the nature of the metal significantly affect the antitumor activity and toxicity of metal 8-quinolinethiolates. The most cytotoxic towards human fibrosarcoma HT-1080 and mouse hepatoma MG-22A tumor cells are the 6-methoxy-8-quinolinethiolates of rhodium, osmium, iridium, indium, antimony, and bismuth, however these are highly toxic towards normal mouse embryonic NIH 3T3 fibroblasts. The iridium 5-methyl-8-quinolinethiolate is somewhat less active to MG-22A cells but shows quite good selectivity of action because of its markedly lower toxicity. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 711–717, May, 2008. |
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Keywords: | metal 3-and 5-methyl-8-quinolinethiolates metal 2-and 6-methoxy-8-quinolinethiolates synthesis toxicity cytotoxicity |
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