4-Hydroxy-2-quinolones 138. Synthesis and study of structure-biological activity relationships in a series of 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-<Emphasis Type="Italic">ij</Emphasis>]quinoline-2-carboxylic acid anilides |
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| Authors: | I V Ukrainets E V Mospanova N L Bereznyakova O I Naboka |
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| Institution: | (1) National University of Pharmacy, Kharkiv, 61002, Ukraine |
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| Abstract: | Two methods are discussed and the synthesis of a series of 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo3,2,1-ij]quinoline-2-carboxylic
acid anilides has been carried out. The antitubercular activity and the effect on the urinary function of the kidney have
been studied for the compounds prepared. A structure-biological activity relationship is discussed.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1808–1819, December, 2007. |
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| Keywords: | anilides 4-hydroxy-2-oxo-1 2-dihydroquinoline-3-carboxylic acids diuretics amidation antitubercular activity |
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