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Gram-scale synthesis of (+)-discodermolide |
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| Authors: | Smith A B Kaufman M D Beauchamp T J LaMarche M J Arimoto H |
| Affiliation: | Department of Chemistry, Monell Chemical Senses Center, University of Pennsylvania 19104, USA. smithab@sas.upenn.edu |
| Abstract: | [formula: see text] A triply convergent, highly efficient second-generation synthesis of the potent antimitotic agent (+)-discodermolide (1) has been achieved on a 1-g scale. |
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