Promiscuous Watson-Crick cross-pairing within the family of pentopyranosyl (4'-->2') oligonucleotides |
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| Authors: | Jungmann O Wippo H Stanek M Huynh H K Krishnamurthy R Eschenmoser A |
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| Institution: | Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, California 92037, USA. |
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| Abstract: | formula: see text] The D-beta-ribo, D-beta-xylo, L-alpha-lyxo, and L-alpha-arabino members of the pentopyranosyl (4'-->2') oligonucleotide family show efficient intersystem cross-pairing among each other. This family of configurationally isomeric and conformationally well-defined pairing systems offers an opportunity to study structural factors that determine cross-communication between informational oligonucleotide systems of different backbone structure. |
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