Effect of substituents in directing the formation of benzochlorins and isobacteriochlorins in porphyrin and chlorin systems |
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| Authors: | Mettath S Li G Srikrishnan T Mehta R Grossman Z D Dougherty T J Pandey R K |
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| Institution: | Department of Nuclear Medicine, and Molecular & Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. |
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| Abstract: | formula: see text] A first synthesis of free-base fluorinated benzochlorins by acid-catalyzed cyclization of 20-(2-trisiloxy-trifluoromethylvinyl)octaethylporphyrin++ + is achieved. Under similar reaction conditions, the purpurin-18-N-hexylimide analogues produced the corresponding fluorinated and nonfluorinated ethylidene-substituted isobacteriochlorins and fluorinated chlorin, respectively. The structure of the porphyrin based fluorinated benzochlorin was also confirmed by X-ray analysis. |
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