Total synthesis of potential antitumor agent, (-)-dictyostatin |
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| Authors: | Ramachandran P Veeraraghavan Srivastava Amit Hazra Debasis |
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| Institution: | Herbert C. Brown Center for Borane Research, Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907-2084, USA. chandran@purdue.edu |
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| Abstract: | structure: see text] The potential antitumor agent (-)-dictyostatin has been synthesized utilizing Brown crotylboration to achieve eight of the eleven chiral centers. The yield for the 26-step longest sequence is approximately 4%. The C9-C10 coupling is achieved via a stereoselective vinylzincate addition. |
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