Palladium-catalyzed cyanation of aryl bromides promoted by low-level organotin compounds |
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| Authors: | Yang Chunhua Williams J Michael |
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| Institution: | Department of Process Research, Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, USA. chunhua_yang@merck.com |
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| Abstract: | A novel method for palladium-catalyzed cyanation of aryl bromides promoted by low-level tri-n-butyltin chloride or cyanide is described. The method features low catalyst loading and mild reaction conditions. KCN is used as the cyanide source. Only trace levels of the tri-n-butyltin compound are required to achieve high conversion and yield in the cyanation of aryl bromides, iodides, and triflates. |
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