A concise enantioselective synthesis of 1-[(S)-3-(dimethylamino)-3,4-dihydro-6,7-dimethoxyquinolin-1(2H)-yl]propan-1-one, (S)-903 |
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| Authors: | Arun R. Jagdale R. Santhosh Reddy Arumugam Sudalai |
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| Affiliation: | Chemical Engineering and Process Development Division, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, Maharashtra 411008, India |
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| Abstract: | A concise enantioselective synthesis of (S)-903, an inotropic agent, is described in nine linear steps and 95% ee based on asymmetric dihydroxylation of cinnamate ester and Co-catalyzed multifunctional reduction of several functional groups leading to the construction of core tetrahydroquinolin-3-ol, as the key steps. |
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