Isolation of (E)-9,10-dihydroxy-2-decenoic acid from royal jelly and determination of the absolute configuration by chemical synthesis |
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| Authors: | Hiroko Tani Shunya Takahashi Keiko Hasumi Tomoki Tatefuji Yayoi Hongo Hiroyuki Koshino |
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| Affiliation: | 1. Institute for Bee Products and Health Science, Yamada Apiculture Center, Inc., Kagamino, Okayama 708-0393, Japan;2. Advanced Science Institute, RIKEN, Wako, Saitama 351-0198, Japan |
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| Abstract: | (E)-9,10-Dihydroxy-2-decenoic acid 1 was isolated as a new compound from royal jelly. The planar structure was deduced by spectroscopic analyses, whereas the absolute configuration was established by chemical synthesis of both enantiomers of 1. The natural product was revealed to be ca. 3.5:1 mixture of (R)- and (S)-acids by comparison of 1 with authentic samples. |
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