Asymmetric synthesis of aza-diospongin A as an iNOS inducer |
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| Authors: | S Chandrasekhar GS Kiran Babu Ch Raji Reddy |
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| Institution: | Organic division-I, Indian Institute of Chemical Technology, Hyderabad 500 607, India |
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| Abstract: | The synthesis of the aza-analogue of diospongin A is described. The key steps in the synthetic sequence are Mitsunobu inversion, cross olefin metathesis and intramolecular aza-Michael addition reactions. The biological activity of this new analogue was also evaluated in the induction of nitric oxide synthase and was found to be better when compared to its natural counterpart. |
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