Stereoselective total synthesis of polyketide lactone, (3R,4S,5S,9S)-3,5,9-trihydroxy-4-methylundecanoic acid δ-lactone |
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| Authors: | Gowravaram Sabitha Peddabuddi Gopal Jhillu S. Yadav |
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| Affiliation: | Organic Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | The total synthesis of lactone 1 has been described. The convergent asymmetric synthesis relies on the use of an Evans’ syn-aldol, chain extension with lithio tert-butyl acetate, and the stereoselective reduction of a ketone as the key reactions. |
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