New highly efficient aziridine-functionalized tridentate sulfinyl catalysts for enantioselective diethylzinc addition to carbonyl compounds |
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| Authors: | Stanisław Leśniak Michał Rachwalski Ewelina Sznajder Piotr Kiełbasiński |
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| Institution: | 1. Department of Organic and Applied Chemistry, University of ?ód?, Narutowicza 68, 90-131 ?ód?, Poland;2. Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Department of Heteroorganic Chemistry, Sienkiewicza 112, 90-363 ?ód?, Poland |
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| Abstract: | New tridentate enantiomerically pure heteroorganic catalysts, containing hydroxyl, sulfinyl, and aziridine moieties, have proven to be highly efficient in the enantioselective diethylzinc addition to aryl and alkyl aldehydes to give the desired products in very high yields (up to 99%) and with ee’s up to 97%. The influence of the stereogenic centers located on the sulfinyl sulfur atom and in the aziridine moiety on the stereochemical course of the reaction are discussed. |
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