A unique approach to the synthesis of a dengue vaccine and the novel tetrasaccharide that results |
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Authors: | Nigel Kevin Jalsa Gurdial Singh |
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Affiliation: | The Department of Chemistry, The University of the West Indies, St. Augustine, Trinidad and Tobago |
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Abstract: | An approach to the development of a dengue vaccine by synthesizing the hexasaccharide epitope on the viral surface is examined. The stereochemical and structural challenges include the synthesis of a β-mannoside bond. Synthesis of this bond is approached via a trisaccharide analogue portion of the epitope. A novel tetrasaccharide with a mannose–mannose anomeric linkage results in the course of the synthetic attempts. |
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