A synthesis of dioctanoyl phosphatidylinositol |
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| Authors: | Thomas S. Elliott Joseph Nemeth Simon A. Swain Stuart J. Conway |
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| Affiliation: | 1. School of Chemistry and Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK;2. Prosidion Ltd, Watlington Road, Oxford OX4 6LT, UK;3. Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK |
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| Abstract: | A synthesis of the naturally occurring enantiomer of phosphatidylinositol is reported. A resolution strategy, using camphor as a chiral auxiliary is employed to obtain the desired, enantiomerically pure, inositol derivative. Dioctanoyl lipid chains are appended to the molecule, which are shorter than the naturally occurring lipid chains, providing the molecule with enhanced water solubility. |
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