An enantioselective synthesis of (+)-azimic acid |
| |
| Authors: | Kai-Jiong Xiao Liang-Xian Liu Pei-Qiang Huang |
| |
| Affiliation: | 1. Department of Chemistry and The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China;2. State Key Laboratory of Bioorganic and Natural Products Chemistry, 354 Fenglin Lu, Shanghai 200032, China |
| |
| Abstract: | Herein we report a concise enantioselective synthesis of (+)-azimic acid starting from (5S,6S)-6-methyl-5-benzyloxy-2-piperidinone 8a, which was prepared from protected (S)-3-hydroxyglutarimide 6 according to a method recently disclosed in our laboratory. The key step is a stepwise regioselective reductive alkylation of the imide 10, which established the 2,6-cis-stereochemistry in excellent diastereoselectivity. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
