A novel simplified synthesis of acivicin |
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Authors: | Andrea Pinto Paola Conti Lucia Tamborini Carlo De Micheli |
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Affiliation: | Dipartimento di Scienze Farmaceutiche‘Pietro Pratesi’, Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy |
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Abstract: | This report describes an efficient synthesis of the natural isomer of acivicin, which is the only one provided with a noteworthy biological activity. The present procedure allowed the synthesis of (+)-1 in just five steps with a 34% overall yield. Due to the easy separation of the two diastereomers and to the availability of the starting material at low cost, the present procedure can be scaled-up to gram quantities. |
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