Asymmetric addition of diethylzinc to aldehydes catalyzed by a camphor-derived β-amino alcohol |
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Authors: | Zhi-Long Wu Hsyueh-Liang Wu Ping-Yu Wu Biing-Jiun Uang |
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Affiliation: | Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan 30013 |
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Abstract: | The asymmetric addition of diethylzinc to aromatic and aliphatic aldehydes, including linear aliphatic ones, catalyzed by 2 mol % of β-amino alcohol (1S, 2R)-7,7-dimethyl-1-morpholin-4-yl-bicyclo[2.2.1]heptan-2-ol 10 gave the corresponding secondary alcohols in high yields and with up to 94% ee at ambient temperature after 15 min. |
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