Stereoselective biotransformations using fungi as biocatalysts |
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Authors: | Keyller Bastos Borges Warley de Souza Borges Rosa Durán-Patrón Mônica Tallarico Pupo Pierina Sueli Bonato Isidro González Collado |
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Affiliation: | 1. Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil;2. Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil;3. Departamento de Química Orgánica, Facultad de Ciencias, Campus Universitario de Puerto Real, Aptdo. 40, Universidad de Cádiz, 11510 Puerto Real (Cádiz), Spain |
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Abstract: | The development of novel biocatalytic methods is a continuously growing area of chemistry, microbiology, and genetic engineering due to the fact that biocatalysts are selective, easy-to-handle, and environmentally friendly. A wide range of reactions are catalyzed by microorganisms. Fungi can be considered as a promising source of new biocatalysts, mainly for chiral reactions. Chemo-, regio-, and stereoselective processes are very important in the synthesis of many chemical, pharmaceutical, and agrochemical intermediates; active pharmaceuticals; and food ingredients. This report reviews stereoselective reactions mediated by fungi, such as stereoselective hydroxylation, sulfoxidation, epoxidation, Baeyer–Villiger oxidation, deracemization, and stereo- and enantioselective reduction of ketones, published between 2000 and 2007. |
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