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Synthesis of simplified analogues of eleutherobin via a Claisen rearrangement/RCM strategy
Authors:SY Frankie Mak  Gary CH Chiang  James EP Davidson  John E Davies  Andrew Ayscough  Gilles Pain  Jonathan W Burton  Andrew B Holmes
Institution:1. Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK;2. British Biotech Pharmaceuticals Ltd, Watlington Road, Oxford, UK;3. Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK;4. School of Chemistry, Bio21 Institute, University of Melbourne, Victoria 3010, Australia
Abstract:The enantioselective synthesis of a number of simplified analogues of the cytotoxic natural product eleutherobin is reported.
Keywords:
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