Enantioselective,copper(I)-catalyzed three-component reaction for the synthesis of β,γ-alkynyl α-amino acid derivatives |
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| Authors: | Zhihui Shao Xuewei Pu Xiaojiao Li Baomin Fan Albert S.C. Chan |
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| Affiliation: | 1. Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China;2. Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, China |
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| Abstract: | The first catalytic asymmetric three-component reaction of ethyl glyoxylate, para-anisidine, and aliphatic, aromatic alkynes catalyzed by CuOTf·0.5C6H6/pybox 7 has been developed. The protocol provided the corresponding chiral β,γ-alkynyl α-amino acid derivatives in good yields and 66–74% ee. |
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