Catalytic asymmetric alkylation of α-cyanocarboxylates and acetoacetates using a phase-transfer catalyst |
| |
Authors: | Kazuhiro Nagata Daisuke Sano Yu Shimizu Michiko Miyazaki Takuya Kanemitsu Takashi Itoh |
| |
Institution: | School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan |
| |
Abstract: | The catalytic asymmetric alkylation of α-cyanocarboxylates and acetoacetates with an alkyl halide was performed under phase-transfer conditions to afford compounds which have a chiral quaternary carbon with up to 97% and 94% ee, respectively. As applications of this method, chiral 2-oxindole derivatives and a β-lactam derivative were synthesized. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|