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Highly stereoselective biocatalytic reduction of alpha-halo ketones |
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| Authors: | Emmanuelle Alanvert Claire Doherty Thomas S. Moody Nicholena Nesbit Andrew S. Rowan Stephen J.C. Taylor Fatima Vaughan Tony Vaughan Jonathan Wiffen Ian Wilson |
| Affiliation: | Biocatalysis Group, Almac Sciences, Almac House, 20 Seagoe, Industrial Estate, Craigavon, Northern Ireland BT63 5QD, United Kingdom |
| Abstract: | The use of recombinant carbonyl reductase biocatalysts for the reduction of alpha-halo ketone intermediates to their corresponding alpha-halo alcohols has been investigated. The alpha-halo alcohol is obtained in good yield from the corresponding ketone in a stereoselective manner. |
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