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Enantioseparations of non-benzenoid and oligo-Tröger’s bases by HPLC on Whelk O1 column |
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| Authors: | Sergey Sergeyev Sara Stas Adrienne Remacle Christophe ML Vande Velde Bohumil Dolenský Martin Havlík Vladimír Král Jan Čejka |
| Institution: | 1. Université Libre de Bruxelles (ULB), Laboratoire de Chimie des Polymères, CP 206/01, Boulevard du Triomphe, 1050 Brussels, Belgium;2. University of Antwerp, Department of Chemistry, Groenenborgerlaan 171, 2020 Antwerp, Belgium;3. Karel de Grote University College, Department of Applied Engineering, Salesianenlaan 30, 2660 Antwerp, Belgium;4. Institute of Chemical Technology, Prague, Department of Analytical Chemistry, Technická 5, Praha 166 28, Czech Republic;5. Institute of Chemical Technology, Prague, Department of Solid State Chemistry, Technická 5, Praha 166 28, Czech Republic |
| Abstract: | The separation of enantiomers of several ‘bis- and tris-Tröger’s bases’ by HPLC on commercially available chiral stationary phase Whelk O1 is described for the first time. The observed structure–enantioselectivity relationships are in agreement with the previously established molecular recognition model. For all ‘bis- and tris-Tröger’s bases’ studied, satisfactory to excellent enantioselectivities were observed. |
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